Publicaciones

Publicaciones[Selección de los últimos años]

2017

 

Borsari, C; Santarem, N; Torrado, J; Olías, A I; Corral, MJ; Baptista, C; Gul, S; Wolf, M; Kuzikov, M; Ellinger, B; Reinshagen, J; Linciano, P; Tait, A; Luca, C; Freitas-Junior, LH; Moraes, CB; Pascoalino, B; Alcântara, L Maria; Franco, CH; Bertolacini, C D; Fontana, V; Tejera Nevado, P; Clos, J; Alunda, J M; Cordeiro-da-Silva, A; Ferrari, S; Costi, M P. (2017). Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds. European Journal Medicinal Chemistry.126:1129-1135.doi: 10.1016/j.ejmech.2016.12.017.DOI: 10.1016/j.ejmech.2016.12.017

 

Ehrlich A., Fernández O.L., Rodriguez-Pinto D., Castilho T.M., Corral-Caridad M.J, Goldsmith-Pestana K , Gore Sarabia N, McMahon-Pratt D. (2017). Local delivery of the TLR9 ligand, CpG, down-regulates host immune and inflammatory responses, ameliorating established Leishmania (Viannia) panamensis chronic infection. Infection and Immunity. 2017; pii: IAI.00981-16. doi: 10.1128/IAI.00981-16. [Epub ahead of print]

 

 

2016

 

Borsari C, Luciani R, Pozzi C, Poehner I, Henrich S, Trande M, Cordeiro-da-Silva A, Santarem N, Baptista C, Tait A, Di Pisa F, Dello Iacono L, Landi G, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Gribbon P, Kohler M, Keminer O, Behrens B, Costantino L, Tejera Nevado P, Bifeld E, Eick J, Clos J, Torrado J, Jiménez-Antón MD, Corral MJ, Alunda JM, Pellati F, Wade RC, Ferrari S, Mangani S, Costi MP (2016). Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.J Med Chem. 2016 Aug 25; 59(16):7598-616. doi: 10.1021/acs.jmedchem.6b00698.

 

Cardoso-Martínez F, de la Rosa J M, Díaz-Marrero A R, Darias J, D’Croz L, Jiménez-Antón MD, Corral MJ, García R, Alunda JM, Cueto M (2016). Oxysterols from an octocoral of the genus Gorgonia from the eastern Pacific of Panama. RSC Advances 6: 38579-38591.

 

Corral MJ, Benito-Peña E, Jiménez-Antón MD, Cuevas L, Moreno-Bondi MC, Alunda JM (2016). Allicin induces calcium and mitochondrial dysregulation causing necrotic death in Leishmania. PLoS Neglected Tropical Diseases 10 (3): e0004525 doi:10.1371/journal.pntd.0004525.

 

Seifert, A., Ehrlich, A., Corral, M.J., Goldsmith-Pestana K, McMahon-Pratt D, Fahmy TM (2016). Immunomodulatory nanoparticles ameliorate disease in the Leishmania (Viannia) panamensis mouse model. Biomaterials. 2016; 108: 168-176.

 

Ribeiro, A.; Fernandes, V.; Martínez-Sainz, P.; López-Oliva, M.E.; Recio, P.; Martínez, A.C.; Blaha, I.; Orensanz, L.M.; Bustamante, S.; García-Sacristán, A.; Prieto, D.; Hernández, M. (2016). Pre- and post-junctional bradykinin B2 receptors regulate smooth muscle tension to the pig intravesical ureter. Neurourology and Urodynamics 35: 115-121. ISSN: 1520-6777. Doi: 10.1002/nau.22685

 

Blaha, I.; Recio, P.; Martínez-Sainz, P.; López-Oliva, M.E.; Ribeiro, A.; Agis-Torres, A.; Martínez, A.C.; Benedito, S.; García-Sacristán, A.; Fernandes, V.; Hernández, M. (2016).Impaired excitatory neurotransmission in the urinary bladder from the obese zucker rat: role of cannabinoid receptors. PLoS ONE 11 (6): e0157424. ISSN: 1932-6203.Doi: 10.1371/journal.pone.0157424

 

Fernandes, V.; Recio, P.; López-Oliva, M.E.; Martínez-Sainz, P.; Ribeiro, A.; Barahona, M.; Martínez, A.C.; Benedito, S.; Agis-Torres, A.; Cabañero, A.; Muñoz, G.M.; García-Sacristán, A.; Orensanz, L.M.; Hernández, M. (2016). Role of endogenous hydrogen sulfide in nerve-evoked relaxation of pig terminal bronchioles. Pulmonary Pharmacology and Therapeutics 41: 1-10. ISSN: 1094-5539. Doi: 10.1016/j.pupt.2016.09.003.

 

Santiago E.; Martínez-Sainz, P.; Climent, B.; Muñoz, M.; Briones, A.M.; Salaíces, M.; García-Sacristán, A.; Rivera, L.; Prieto, D. (2016). Augmented oxidative stress and preserved vasoconstriction induced by hydrogen peroxide in coronary arteries in obesity: role of COX-2. British Journal of Pharmacology 173 (22): 3176-3195. ISSN: 0007-1184.Doi: 10.1111/bph.13579

 

 

2015

 

Luzón M, Domínguez-González J, Soto-Carrión AM, Alunda JM, de la Fuente C (2015). Sarcocystosis in Cervus elaphus: comparison of diagnostic methods. International Journal for Parasitology: Parasites and Wildlife 4: 396-400.

 

Fawzi EM, González-Sánchez ME, Corral MJ, Alunda JM, Cuquerella M (2015) Vaccination of lambs with the recombinant protein rHc23 elicits significant protection against Haemonchus contortus challenge. Veterinary Parasitology 211(1-2):54-59. doi: 10.1016/j.vetpar.2015.04.029. Epub 2015 May 8.

 

Muñoz, M.; Sánchez, A.; Martínez-Sainz, P.; Benedito, S.; López-Oliva, E.; S.; García-Sacristán, A.; Hernández, M.; Prieto, D. (2015). COX-2 is involved in vascular oxidative stress and endothelial dysfunction of renal interlobar arteries from obese Zucker rats. Free Radical Biology and Medicine 84: 77-90. ISSN: 0891-5849. Doi: 10.1016/j.freeradbiomed.2015.03.024

 

 

 

2014

 

Corral MJ, Serrano DR, Moreno I, Torrado JJ, Domínguez M, Alunda JM (2014). Efficacy of low doses of Amphotericin B plus allicin against experimental visceral leishmaniasis. Journal of Antimicrobial Chemotherapy 69: 3268-3274. doi: 10.1093/jac/dku290.

 

Fawzi EM, González-Sánchez ME, Corral MJ, Cuquerella M, Alunda JM (2014). Vaccination of lambs against Haemonchus contortus infection with a somatic protein (Hc23) from adult helminths. International Journal for Parasitology 44:429-436. doi: 10.1016/j.ijpara.2014.02.009.

 

González-Sánchez E, Corral MJ, Fawzi EM, Rodríguez-Bertos A, Alunda JM, Cuquerella M. (2014). LPS and inactivated Propionibacterium acnes elicit a partially protective response in primary infections of Heligmosomoides polygyrus.Veterinary Parasitology 203: 231-236. doi: 10.1016/j.vetpar.2014.02.026.

 

Corral, M.J.; González-Sánchez, E.; Cuquerella, M. & J.M.Alunda (2014). In vitro synergistic effect of amphotericin B and allicin on Leishmania donovani and L.infantum. Antimicrobial Agents and Chemotherapy 58: 1596-1602. doi:10.1128/AAC.00710-13.

 

Ribeiro, A.S.F; Fernandes, V.S.; Martínez-Sainz, P.; Martínez Saenz, A.; Pazos, R.; Orensanz, L.M.; Recio, P.; Bustamante, S.; Carballido, J.; García-Sacristán, A.; Prieto, D.; Hernández, M. (2014). Neuronal and non-neuronal bradykinin receptors are involved in the contraction and/or relaxation to the pig bladder neck smooth muscle. Neurourology and Urodynamics 33 (5): 558-565.ISSN: 1520-6777.Doi: 10.1002/nau.22434

 

Ribeiro, A.S.F; Fernandes, V.S.; Martínez Saenz, A.; Martínez-Sainz, P.; Barahona, M.V.; Orensanz, L.M.; Blaha, I.; Serrano-Margüello, D.; Bustamante, S.; Carballido, J.; García-Sacristán, A.; Prieto, D.; Hernández, M. (2014). Powerful relaxation of phosphodiesterase type 4 inhibitor rolipram in the pig and human bladder neck.The Journal of Sexual Medicine 11 (4): 930-941.ISSN: 1743-6109.Doi: 10.1111/jsm.12456

 

Sánchez, A.; Contreras, C.; Martínez Sainz, P.; Muñoz, M.; Martínez, A.C.; García-Sacristán, A.; Hernández; M.; Prieto, D. (2014). Endothelin ETA receptors are involved in the augmented adrenergic vasoconstriction and in the blunted nitric oxide-mediated relaxations of penile arteries from insulin resistant obese Zucker rats. The Journal of Sexual Medicine 11 (6): 1463-1474.ISSN: 1743-6109. Doi: 10.1111/jsm.12526

 

Martínez, A.C.; Hernández, M.; Novella, S.; Martínez-Sainz, P.; Pagán, R.; Hernenegildo, C.; García-Sacristán, A.; Prieto, D.; Benedito, S. (2014). Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives.PLoS ONE 9 (9): e106372.ISSN: 1932-6203.Doi: 10.1371/journal.pone.0106372

 

Climent, B. Moreno, L.; Martínez-Sainz, P.; Contreras, C.; Sánchez, Pérez-Vizcaíno, A.; García-Sacristán, A.; Rivera, L.; Prieto, D. (2014). Upregulation of SK3 and IK1 channels contributes to the enhanced endothelial calcium signaling and the preserved coronary relaxation in obese Zucker rats. PLoS ONE 9 (10): e109432.Doi: 10.1371/journal.pone.0109432

 

Fernandes, V.; Ribeiro, A.S.; Martínez-Sainz, P.; López-Oliva, E.; Barahona, V.; Orensanz, L.M.; Martínez-Saenz, A.; Recio, P.; Benedito, S.; Bustamante, S.; García-Sacristán, A.; Prieto, D.; Hernández, M. (2014). Hydrogen sulfide plays a key role in the inhibitory neurotransmission to the pig intravesical ureter. PLoS ONE 9 (11): e113580.ISSN: 1932-6203.Doi: 10.1371/journal.pone.0113580

 

Sánchez, A.; Martínez Sainz, P.; Muñoz, M.; Benedito, S.; García-Sacristán, A.; Hernández; M.; Prieto, D. (2014). Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ETA and ETB receptors. British Journal of Pharmacology 171 (24): 5682-5695.Doi: 10.111/bph.12870

 

 

2013

 

Alunda, J.Mª (2013). Tratamiento de la leishmaniosis desde una perspectiva veterinaria. An. R. Acad. CC. Vet. España 21: 309-336.

 

Fawzi, EM.; Cruz Bustos, T.; Gómez Samblas, M.; González González G.; Solano, J.;González Sánchez, M.E.; de Pablos, L.M.; Corral Caridad M.J.; Cuquerella, M.; Osuna, A. & J.M. Alunda (2013). Intranasal immunization of lambs with serine/threonine phosphatase 2A (PP2A) against gastrointestinal nematodes. Clinical and Vaccine Immunology 20:9: 1352-1359. doi:10.1128/CVI.00336-13.

 

Corral, M.J.; González, E.; Cuquerella, M. & J.M. Alunda (2013). Improvement of 96-well microplate assay for estimation of cell growth and inhibition of Leishmania with Alamar Blue. Journal of Microbiological Methods 94: 111-116. doi: 10.1016/j.mimet.2013.05.012

 

Corral-Caridad, M.J. & J.M. Alunda (2013). Chemotherapy of leishmaniasis: a veterinary perspective. In: Trypanosomatid diseases. Molecular routes to drug discovery (Edits. Jäger, T., Koch, O., Flohé, L.). Drug Discovery in Infectious Diseases (Edit. Selzer, P.M.). pp. 17-36. ISBN 978-3-527-33255-7 Wiley-VCH, Weinheim

 

Fernandes, V.S.; Ribeiro, A.S.F.; Martínez-Sainz, P.; Orensanz, L.M.; Barahona, M. V.; Martínez Saenz, A.; Recio, P.; Benedito, S.; Bustamante, S.; Carballido, J.; García-Sacristán, A.; Prieto, D.; Hernández, M. (2013). Endogenous hydrogen sulfide plays a powerful role in the inhibitory neurotransmission to the pig bladder neck. Journal of Urology 189 (4):1567-1573.ISSN: 0022-5347.Doi: 10.1016/j.juro.2012.10.006

 

Contreras, C.; Sánchez, A.; Martínez-Sainz, P.; Climent, B.; Benedito, S.; García-Sacristán, A.; Hernández, M.; Prieto, D. (2013). Impaired endothelin calcium signaling coupled to endothelin type B receptors in penile arteries from insulin-resistant obese Zucker rats.The Journal of Sexual Medicine 10 (9): 2141-2153.ISSN: 1743-6109. Doi: 10.1111/jsm.12234

 

 

2012

 

Corral-Caridad, M.J.; Moreno, I.; Toraño, A.; Domínguez, M. & J.M. Alunda (2012). Effect of allicin on promastigotes and intracellular amastigotes of Leishmania donovani and L.infantum. Experimental Parasitology 132:475-482. Doi: http://dx.doi.org/10.1016/j.exppara.2012.08.016.

 

Arteaga, J.L.; Orensanz, L.M.; Martínez Sainz, P.; Barahona, V.; Recio, P.; Martínez Sáenz, A.; Fernandes, V.S. Ribeiro, A.; García Sacristán, A.; Prieto, D; Hernández, M. (2012). Mechanisms involved in Endothelin-1-induced contraction of the pig urinary bladder neck. Neurourology and Urodynamics 31 (1): 156-161.ISSN: 1520-6777

Doi: 10.1002/nau.21187.

 

Pagán, R., Martínez, C.; Martínez Sainz, P.; Hernández, M.; García Sacristán, A.; Correa, C. Novella, S. Hermenegildo, C. Prieto, D.; Benedito, S. (2012).Endothelial and neural factors functionally involved in the modulation of noradrenergic vasoconstriction in healthy pig internal mammary artery. Biochemical Pharmacology 83 (7): 882-892

ISSN: 0006-2952.Doi: 10.1016/j.bcp.2011.12.038

 

Arteaga, J.L.; Orensanz, L.M.; Martínez Sainz, P.; Barahona, V.; Martínez Sáenz, A.; Fernandes, V.S.; Bustamante, S.; Carballido, J. Benedito, S.; García Sacristán, A.; Prieto, D.; Hernández, M. (2012). Endothelin ETB receptors are involved in the relaxation to the pig urinary bladder neck. Neurourology and Urodynamics 31 (5): 688-694. ISSN: 1520-6777.Doi: 10.1002/nau.22203.

 

Sánchez, A.; Contreras, C.; Martínez-Sainz, P.; Climent, B.; Benedito, S.; García-Sacristán, A.; Hernández, M.; Prieto, D. (2012). Role of Neural NO Synthase (nNOS) Uncoupling in the Dysfunctional Nitrergic Vasorelaxation of Penile Arteries from Insulin-Resistant Obese Zucker Rats. PLoS ONE 7 (4): e36027.ISSN: 1932-6203. Doi: 10.1371/journal.pone.0036027.

 

 

2011

 

Wert, L.; Alakurtti, S.; Corral, M.J.; Sánchez-Fortún, S.; Yli-Kauhaluoma, J. & J.M. Alunda (2011). Toxicity of betulin derivatives and in vitro effect on promastigotes and amastigotes of Leishmania infantum and L. donovani. Journal of Antibiotics 64:475-481. doi:10.1038/ja.2011.34.

 

Cuquerella, M.; Fawzi, E.M.; Paramio, R. & J.M. Alunda (2011). Immunisation of rabbits with house dust mite extract does not protect against infection by Graphidium strigosum. Revista Ibero-Latinoamericana de Parasitología 70: 58-64 

 

Fernandes, V.S.; Martínez Sáenz, A.; Recio, P.; Ribeiro, A.S.F.; Sánchez, A.; Martínez Sainz, P.; Martínez, A.C.; García Sacristán, A.; Orensanz, L.M.; Prieto, D.; Hernández, M. (2011). Mechanism involved in the nitric oxide-induced vasorelaxation in porcine prostatic small arteries. Naunyn-Schmiedeberg’s Archives of Pharmacology 384 (3): 245-253.ISSN: 0028-1298.Doi: 10.1007/500210-011-0666-2

 

Ribeiro A.; Fernandes, V.S.; Orensanz, L.M.; Martínez Sainz, P.; Recio, P.; Martínez Sáenz, A.; Arteaga, J.L.; García Sacristán, A.; Prieto, D; Hernández, M. (2011)Mechanisms involved in the adenosine-induced vasorelaxation to the pig prostatic small arteries. Purinergic Signalling 7 (4): 413-425.ISSN: 1573-9538.Doi: 10.1007/511302-011-9238-7.

 

Martínez Sáenz, A.; Recio, P.; Orensanz, L.M.; Fernandes, V.S.; Martínez Sainz, P.; Bustamante, S.; Carballido, J.; García Sacristán, A.; Prieto, D.; Hernández, M. (2011). Role of calcitonin gene-related peptide in inhibitory neurotransmission to the pig urinary bladder neck. Journal of Urology 186 (2): 728-735.Doi: 10.1016/j.juro.2011.03.142

 

 

2010

 

García-Coiradas, L.; Angulo-Cubillán, F.; Valladares, B.; Martínez, E.; de la Fuente, C.; Alunda, J.M. & M. Cuquerella (2010). Immunization against lamb haemonchosis with a recombinant somatic antigen of Haemonchus contortus (rHcp26/23).

Veterinary Medicine International. http://downloads.sage-hindawi.com/ journals/vmi/2010/852146.pdf

 

Angulo-Cubillán, F.; García-Coiradas, L.; Alunda, J.M.; Cuquerella, M. & C. de la Fuente. (2010). Biological characterization and pathogenicity of three Haemonchus contortus isolates in primary infections in lambs. Veterinary Parasitology 171: 99-105. doi: 10.1016/j.vetpar.2010.03.004

Hernández-Rodríguez, S.; Hidalgo-Argüello, M.R. & de la Fuente-López, C. (Edit.) (2010).Parasitosis de Animales Silvestres y Ambiente Sostenible. La Interfaz Animal Silvestre / Animal Doméstico (Parasitic Diseases of Wild Animals and Sustainable Environment. The Wild / Domestic Animal Interface). Universidad Complutense de Madrid, Madrid.ISBN: 978-84-96704-05-3  

Sánchez, A.; Contreras, C.; Villalba N.; Martínez Sainz, P.; Martínez, C.; García Sacristán, A, Salaíces, M. Hernández, M.; Prieto D. (2010). Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats. British Journal of Pharmacology 159 (3): 604-616.ISSN: 0007-1184.Doi: 10.111/j.1476-5381.2009.00553.X

 

Luzón, M.; de la Fuente-López, C.; Martínez-Nevado, E.; Fernández-Morán, J. & Ponce-Gordo, F. (2010).Taenia crassiceps cysticercosis in a ring-tailed lemur (Lemur catta). Journal of Zoo and Wildlife Medicine, 41 (2): 327-330.            

 

Domínguez, J.; Panadero, R. & de la Fuente-López, C. (2010). Detection of Hypoderma actaeon infestation in Cervus elaphus with ELISA and Western Blotting.

Journal of Wildlife Diseases, 46 (3): 934-938.

 

Contreras, C.; Sánchez, A.; Martínez Sainz, P.; Raposo, R.; Climent, B.; García Sacristán, A.; Benedito, S.; Prieto, D. (2010). Insulin resistance in penile arteries from a rat model of metabolic syndrome. British Journal of Pharmacology 161 (2): 350-364

ISSN: 0007-1184.Doi: 10.111/j.1476-5381.2010.00825.X

 

Sánchez, A.; Contreras, C.; Martínez Sainz, P.; Villalba, N.; Benedito, S.; García Sacristán, A.; Salaices, M.; Hernández, M.; Prieto, D. (2010). Enhanced cyclooxygenase 2-mediated vasorelaxation in coronary arteries from insulin-resistant obese Zucker rats. Atherosclerosis 213 (2): 392-399.ISSN: 0021-9150.Doi: 10.1016/j.atherosclerosis.2010.09.022.

 

 

2009

 

Urbano, J.; Sánchez-Moreno, M.; Ordóñez, L.; Longoni, S.Z.; Olmo, F.; Rosales, M.J.; Alunda. J.M.; Gutiérrez-Sánchez, R. & Marín, C. (2009). Canine leishmanioses: new isolates in Madrid (Spain). Revista Ibero-Latinoamericana de Parasitología 68: 108-117.

 

Ordóñez-Gutiérrez, L.; Martínez, M.; Rubio-Somoza, I.; Díaz, I.; Méndez, S. & J.M. Alunda (2009). Leishmania infantum: Antiproliferative effect of recombinant plant cystatins on promastigotes and intracellular amastigotes estimated by direct counting and Real-Time PCR. Experimental Parasitology 123: 341-346. doi: 10.1016/j.exppara.2009.08.015

 

Cuquerella, M. & Alunda, J.M. (2009). Immunobiological characterization of Graphidium strigosum experimental infections in rabbits (Oryctolagus cuniculus). Parasitology Research 104: 371-376. doi: 10.1007/s00436-008-1206-y

 

García-Coiradas, L.; Angulo-Cubillán, F.; S. Méndez; V. Larraga; C. de la Fuente; M. Cuquerella & J.M. Alunda, J.M. (2009). Isolation and immunolocalization of a putative protective antigen (p26/23) from adult Haemonchus contortus. Parasitology Research 104 : 363-369. doi: 10.1007/s00436-008-1204-0

 

Santín-Durán, M.; Alunda, J.M.; Hoberg, E.P. & de la Fuente, C. (2008). Age distribution and seasonal dynamics of abomasal helminths in wild red deer from Central Spain. Journal of Parasitology 94: 1031-1037

 

Villalba N.; Martínez Sainz, P.; Briones, A.M.; Sánchez, A.; Salaíces, M.; García Sacristán, A.; Hernández, M.; Benedito, S.; Prieto D. (2009). Differential structural and functional changes in penile and coronary arteries from obese Zucker rats. American Journal of Physiology - Heart and Circulatory Physiology 297: 696-707.Doi: 10.1152/ajpheart.01308.2008

 

Pagán, R.M.; Martínez, A.C.; Martínez Sainz, P.; Hernández, M.; García Sacristán, A.; Correa, C; Prieto, D.; Benedito, S. (2009). Endothelial and potassium channel dependent modulation of noradrenergic vasoconstriction in the pig radial artery. European Journal of Pharmacology 616: 166-174.Doi: 10.1016/j.ejphar.2009.06.002